Citrus aurantium

EVIDENCIAS CIENTÍFICAS  DE LA INTERVENCIÓN NATUROPÁTICA

1. Ahmadi, A., & Shadboorestan, A. (2015). Oxidative Stress and Cancer; The Role of   Hesperidin, a Citrus Natural Bioflavonoid, as a Cancer Chemoprotective Agent. Nutrition and   cancer, 1-12.

2. Alam, M. A., Subhan, N., Rahman, M. M., Uddin, S. J., Reza, H. M., & Sarker, S. D. (2014). Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Advances in Nutrition: An International Review Journal, 5(4), 404-417.

3. Ameer, B., Weintraub, R. A., Johnson, J. V., Yost, R. A., & Rouseff, R. L. (1996). Flavanone absorption after naringin, hesperidin, and citrus administration. Clinical Pharmacology &Therapeutics, 60(1), 34-40.

4. Aptekmann, N. P., & Cesar, T. B. (2010). Orange juice improved lipid profile and blood lactateof overweight middle-aged women subjected to aerobic training. Maturitas, 67(4), 343-347.

5. Arbo, M. D., Larentis, E. R., Linck, V. M., Aboy, A. L., Pimentel, A. L., Henriques, A. T., … &Limberger, R. P. (2008). Concentrations of p-synephrine in fruits and leaves of Citrus species

(Rutaceae) and the acute toxicity testing of Citrus aurantium extract and p-synephrine. Foodand chemical toxicology, 46(8), 2770-2775.

6. Arbo, M. D., Schmitt, G. C., Limberger, M. F., Charão, M. F., Moro, Â. M., Ribeiro, G. L., …& Limberger, R. P. (2009). Subchronic toxicity of Citrus aurantium L.(Rutaceae) extract and psynephrine in mice. Regulatory Toxicology and Pharmacology,54(2), 114-117.

7. Arias, B. A., & Ramón-Laca, L. (2005). Pharmacological properties of citrus and their ancient and medieval uses in the Mediterranean region. Journal of Ethnopharmacology, 97(1), 89-95.

8. Asgary, S., & Keshvari, M. (2013). Effects of citrus sinensis juice on blood pressure. ARYAatherosclerosis, 9(1), 98.

9. Avula, B., Upparapalli, S. K., Navarrete, A., & Khan, I. A. (2005). Simultaneous quantificationof adrenergic amines and flavonoids in C. aurantium, various Citrus species, and dietarysupplements by liquid chromatography. Journal of AOAC International,88(6), 1593-1606.

10. Bae, J. M., Lee, E. J., & Guyatt, G. (2008). Citrus fruit intake and stomach cancer risk: aquantitative systematic review. Gastric Cancer, 11(1), 23-32.

11. Bae, J. M., Lee, E. J., & Guyatt, G. (2008). Citrus fruits intake and prostate cancer risk: aquantitative systematic review. J Prev Med Public Health, 41(3), 159-164.

12. Bailey, D. G., Spence, J. D., Munoz, C., & Arnold, J. M. O. (1991). Interaction of citrus juiceswith felodipine and nifedipine. The Lancet, 337(8736), 268-269.

13. Baldwin, E. A., Nisperos-Carriedo, M., Shaw, P. E., & Burns, J. K. (1995). Effect of coatingand prolonged storage conditions on fresh orange flavor volatiles, degrees Brix, and ascorbicacid levels. Journal of Agricultural and food chemistry, 43(5), 1321-1331.

14. Barreca, D., Bellocco, E., Caristi, C., Leuzzi, U., & Gattuso, G. (2011). Distribution of C-andO-glycosyl flavonoids,(3-hydroxy-3-methylglutaryl) glycosyl flavanones and furocoumarins inCitrus aurantium L. juice. Food Chemistry,124(2), 576-582.

15. Barreca, D., Gattuso, G., Laganà, G., Leuzzi, U., & Bellocco, E. (2016). C-and O-glycosylflavonoids in Sanguinello and Tarocco blood orange (Citrus sinensis (L.) Osbeck) juice:Identification and influence on antioxidant properties and acetylcholinesterase activity. Foodchemistry, 196, 619-627.

16. BasiLe, L. G., Lima, C. G., & Cesar, T. B. (2010). Daily intake of pasteurized orange juicedecreases serum cholesterol, fasting glucose and diastolic blood pressure in adults. In Proc.Florida State Hortic. Soc (Vol. 123, pp. 228-233).

17. Benavente-Garcia, O., & Castillo, J. (2008). Update on uses and properties of citrus flavonoids:new findings in anticancer, cardiovascular, and anti-inflammatory activity. Journal ofagricultural and food chemistry, 56(15), 6185-6205.

18. Benavente-García, O., Castillo, J., Marin, F. R., Ortuño, A., & Del Río, J. A. (1997). Uses andproperties of citrus flavonoids. Journal of Agricultural and Food Chemistry, 45(12), 4505-4515.

19. Bent, S., Padula, A., & Neuhaus, J. (2004). Safety and efficacy of citrus aurantium for weightloss. The American journal of cardiology, 94(10), 1359-1361.

20. Betoret, E., Betoret, N., Carbonell, J. V., & Fito, P. (2009). Effects of pressure homogenizationon particle size and the functional properties of citrus juices. Journal of foodengineering, 92(1), 18-23.

21. Bodet, C., La, V. D., Epifano, F., & Grenier, D. (2008). Naringenin has anti ‐inflammatoryproperties in macrophage and ex vivo human whole ‐blood models. Journal of periodontalresearch, 43(4), 400-407.

22. Bok, S. H., Lee, S. H., Park, Y. B., Bae, K. H., Son, K. H., Jeong, T. S., & Choi, M. S. (1999).Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoAreductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or amixture of citrus bioflavonoids.The Journal of nutrition, 129(6), 1182-1185.

23. Bonamin, F., Moraes, T. M., dos Santos, R. C., Kushima, H., Faria, F. M., Silva, M. A., … & daRocha, L. R. (2014). The effect of a minor constituent of essential oil from Citrus aurantium:The role of β-myrcene in preventing peptic ulcer disease. Chemico-biological interactions, 212,11-19.

24. Bonifacio, N. P., & César, T. B. (2007). Influência da ingestão regular do suco de laranja naredução da pressão arterial. Nutr Pauta, 83, 37-40.

25. Borradaile, N. M., Carroll, K. K., & Kurowska, E. M. (1999). Regulation of HepG2 cellapolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin. Lipids, 34(6),591-598.

26. Bredsdorff, L., Nielsen, I. L. F., Rasmussen, S. E., Cornett, C., Barron, D., Bouisset, F., … &Williamson, G. (2010)Absorption, conjugation and excretion of the flavanones, naringeninand hesperetin from α-rhamnosidase-treated orange juice in human subjects. British journal ofnutrition, 103(11), 1602-1609.

27. Brett, G. M., Hollands, W., Needs, P. W., Teucher, B., R Dainty, J., Davis, B. D., … & Kroon, P.A. (2009). Absorptionmetabolism and excretion of flavanones from single portions of orangefruit and juice and effects oanthropometric variables and contraceptive pill use on flavanoneexcretion. British journal of nutrition, 101(05), 664-675.

28. Bronner, W. E., & Beecher, G. R. (1995). Extraction and measurement of prominent flavonoidsin orange and grapefruit juice concentrates. Journal of Chromatography A, 705(2), 247-256.

29. Bruemmer, J. H., Roe, B., & Bowen R. (1976). Peroxidase reactions and orange juice quality.Journal of Food Science, 41(1), 186-189.

30. Bub, A., Watzl, B., Blockhaus, M., Briviba, K., Liegibel, U., Müller, H., … & Rechkemmer, G.(2003). Fruit juice consumption modulates antioxidative status, immune status and DNAdamage. The Journal of nutritional biochemistry, 14(2), 90-98.

31. Burgess, J. R., & Andrade, J. E. (2006). Antioxidant effects of citrus flavonoid consumption.Potential Health Benefits of Citrus, 936, 161-174.

32. Buscemi, S., Rosafio, G., Arcoleo, G., Mattina, A., Canino, B., Montana, M., … & Rini, G.(2012). Effects of red orange juice intake on endothelial function and inflammatory markers in

adult subjects with increased cardiovascular risk. The American journal of clinicalnutrition, 95(5), 1089-1095.

33. Calapai, G., Firenzuoli, F., Saitta, A., Squadrito, F., Arlotta, M. R., Costantino, G., & Inferrera,G. (1999). Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: apreliminary report. Fitoterapia, 70(6), 586-592.

34. Cao, S., Liu, L., Lu, Q., Xu, Y., Pan, S., & Wang, K. (2009). Integrated effects of ascorbic acid,flavonoids and sugars on thermal degradation of anthocyanins in blood orange juice. EuropeanFood Research and Technology, 228(6), 975-983.

35. Carvalho-Freitas, M. I. R., & Costa, M. (2002). Anxiolytic and sedative effects of extracts andessential oil from Citrus aurantium L. Biological and Pharmaceutical Bulletin, 25(12), 1629-1633.

36. Castillo, J., Benavente, O., & del Rio, J. A. (1993). Hesperetin 7-O-glucoside and prunin inCitrus species (Caurantium and C. paradisi). A study of their quantitative distribution inimmature fruits and as immediate precursors of neohesperidin and naringin in Citrusaurantium. Journal of Agricultural and Food Chemistry, 41(11), 1920-1924.

37. Celano, M., Maggisano, V., De Rose, R. F., Bulotta, S., Maiuolo, J., Navarra, M., & Russo, D.(2015). Flavonoid Fractioof Citrus Reticulata Juice Reduces Proliferation and Migration ofAnaplastic Thyroid Carcinoma Cells. Nutritionand Cancer, 67(7), 1183-1190.

38. Cerletti, C., Gianfagna, F., Tamburrelli, C., De Curtis, A., D’Imperio, M., Coletta, W., … &Rotilio, D. (2015). Orange juice intake during a fatty meal consumption reduces thepostprandial low-grade inflammatory response in healthy subjects.Thrombosis research,135(2), 255-259.

39. Cesar, T. B., Aptekmann, N. P., Araujo, M. P., Vinagre, C. C., & Maranhão, R. C. (2010).Orange juice decreases lodensity lipoprotein cholesterol in hypercholesterolemic subjectsand improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemicsubjects. Nutrition Research,30(10), 689-694.

40. César, T. B., Rodrigues, L. U., Araújo, M. S. P. D., & Aptekmann, N. P. (2010). Suco de laranjareduz o colesterol eindivíduos normolipidêmicos. Revista de Nutrição, 779-789.

41. Chau, C. F., & Huang, Y. L. (2003). Comparison of the chemical composition andphysicochemical properties of different fibers prepared from the peel of Citrus sinensis L. Cv.Liucheng. Journal of Agricultural and Food Chemistry, 51(9), 2615-2618.

42. Chiba, H., Uehara, M., Wu, J., Wang, X., Masuyama, R., Suzuki, K., … & Ishimi, Y. (2003).Hesperidin, a citrus flavonoidinhibits bone loss and decreases serum and hepatic lipids inovariectomized mice. The Journal of nutrition, 133(6), 1892-1897.

43. Cho, H. W., Jung, S. Y., Lee, G. H., Cho, J. H., & Choi, I. Y. (2015). Neuroprotective effect ofCitrus unshiu immaturpeel and nobiletin inhibiting hydrogen peroxide-induced oxidativestress in HT22 murine hippocampal neuronal cells. Pharmacognosy magazine, 11(Suppl 2),S284.

44. Choudhury, R., Chowrimootoo, G., Srai, K., Debnam, E., & Rice-Evans, C. A. (1999).Interactions of the flavonoinaringenin in the gastrointestinal tract and the influence ofglycosylation. Biochemical and biophysical research communications, 265(2), 410-415.

45. Coelho, R. C. L. A., Hermsdorff, H. H. M., & Bressan, J. (2013). Anti-inflammatory propertiesof orange juice: possible favorable molecular and metabolic effects. Plant foods for humannutrition, 68(1), 1-10.

46. Coleman, R. L., Lund, E. D., & Moshonas, M. G. (1969). Composition of orange essenceoil. Journal of Food Science, 34(6), 610-611.

47. Colker, C. M., Kaiman, D. S., Torina, G. C., Perlis, T., & Street, C. (1999). Effects of Citrusaurantium extract, caffeine, and St. John’s wort on body fat loss, lipid levels, and mood states inoverweight healthy adults. Current Therapeutic Research, 60(3), 145-153.

48. Da Silva, J. (2005). Influence of orange juice over the genotoxicity induced by alkylatingagents: an in vivo analysisMutagenesis, 20(4), 279-283.

49. Dallas, C., Gerbi, A., Tenca, G., Juchaux, F., & Bernard, F. X. (2008). Lipolytic effect of apolyphenolic citrus dry extracof red orange, grapefruit, orange (SINETROL) in human bodyfat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE).Phytomedicine,15(10), 783-792.

50. De Moraes Pultrini, A., Galindo, L. A., & Costa, M. (2006). Effects of the essential oil fromCitrus aurantium L. in experimental anxiety models in mice. Life Sciences, 78(15), 1720-1725.

51. Demonty, I., Lin, Y., Zebregs, Y. E., Vermeer, M. A., van der Knaap, H. C., Jäkel, M., &Trautwein, E. A. (2010). The citrus flavonoids hesperidin and naringin do not affect serumcholesterol in moderately hypercholesterolemic men and  women. The Journal ofnutrition, 140(9), 1615-1620.

52. Deopurkar, R., Ghanim, H., Friedman, J., Abuaysheh, S., Sia, C. L., Mohanty, P., … &Dandona, P. (2010). Differentia effects of cream, glucose, and orange juice on inflammation,  endotoxin, and the expression of Toll-like receptor-4 an suppressor of cytokine signaling-3.Diabetes care, 33(5), 991-997.

53. Devaraj, S., Jialal, I., & Vega-López, S. (2004). Plant sterol-fortified orange juice effectivelylowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(3), e25-e28.

54. Devaraj, S., Jialal, I., Rockwood, J., & Zak, D. (2011). Effect of orange juice and beverage withphytosterols on cytokines and PAI-1 activity. Clinical Nutrition,30(5), 668-671.

55. Deyhim, F., Garica, K., Lopez, E., Gonzalez, J., Ino, S., Garcia, M., & Patil, B. S. (2006).Citrus juice modulates bone strength in male senescent rat model of osteoporosis.Nutrition, 22(5), 559-563.

56. Dhuique-Mayer, C., Caris-Veyrat, C., Ollitrault, P., Curk, F., & Amiot, M. J. (2005). Varietaland interspecific influence on micronutrient contents in citrus from the Mediterranean area.Journal of Agricultural and Food Chemistry, 53(6), 2140-2145.

57. Di Donna, L., De Luca, G., Mazzotti, F., Napoli, A., Salerno, R., Taverna, D., & Sindona, G.(2009). Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides. Journal of natural products,72(7), 1352-1354.

58. Dugo, P., Lo Presti, M., Öhman, M., Fazio, A., Dugo, G., & Mondello, L. (2005).Determination of flavonoids in citrus juices by micro ‐ HPLC ‐ESI/MS.Journal of SeparationScience, 28(11), 1149-1156.

59. Erlund, I. (2004). Review of the flavonoids quercetin, hesperetin, and naringenin. Dietarysources, bioactivities, bioavailability, and epidemiology. Nutrition Research, 24(10), 851-874.

60. Erlund, I., Kosonen, T., Alfthan, G., Mäenpää, J., Perttunen, K., Kenraali, J., … & Aro, A.(2000). Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers.European journal of clinical pharmacology, 56(8), 545-553.

61. Erlund, I., Meririnne, E., Alfthan, G., & Aro, A. (2001). Plasma kinetics and urinary excretionof the flavanones naringenin and hesperetin in humans after ingestion of orange juice andgrapefruit juice. The Journal of nutrition, 131(2), 235-241.

62. Erlund, I., Silaste, M. L., Alfthan, G., Rantala, M., Kesäniemi, Y. A., & Aro, A. (2002). Plasmaconcentrations of the flavonoids hesperetin, naringenin and quercetin in human subjectsfollowing their habitual diets, and diets high or low in fruit and vegetables. European journalof clinical nutrition, 56(9), 891-898.

63. Fan, K., Kurihara, N., Abe, S., Ho, C. T., Ghai, G., & Yang, K. (2007). ChemopreventiveEffects of Orange Peel Extract (OPE) I. OPE Inhibits Intestinal Tumor Growth in ApcMin/+Mice. Journal of medicinal food,10(1), 11-17.

64. Faturi, C. B., Leite, J. R., Alves, P. B., Canton, A. C., & Teixeira-Silva, F. (2010). Anxiolytic-
like effect of sweet orange aroma in Wistar rats. Progress in Neuro-Psychopharmacology andBiological Psychiatry, 34(4), 605-609.

65. Ferlazzo, N., Cirmi, S., Russo, M., Trapasso, E., Ursino, M. R., Lombardo, G. E., … & Navarra,M. (2016). NF- κB mediates the antiproliferative and proapoptotic effects of bergamot juice inHepG2 cells. Life Sciences.

66. Firenzuoli, F., Gori, L., & Galapai, C. (2005). Adverse reaction to an adrenergic herbal extract(Citrus aurantium). Phytomedicine, 12(3), 247-248.

67. Fisher, K., & Phillips, C. A. (2006). The effect of lemon, orange and bergamot essential oilsand their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeriamonocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systems.Journal of Applied Microbiology, 101(6), 1232-1240.

68. Fomani, M., Happi, E. N., Bisoue, A. N., Ndom, J. C., Waffo, A. F. K., Sewald, N., & Wansi, J.D. (2016). Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloidsfrom Citrus reticulate (Blanco). Bioorganic & medicinal chemistry letters, 26(2), 306-309.

69. Franke, A. A., Cooney, R. V., Custer, L. J., Mordan, L. J., & Tanaka, Y. (1998). Inhibition ofneoplastic transformation and bioavailability of dietary flavonoid agents. Flavonoids in theliving system, 237-48.

70. Franke, A. A., Cooney, R. V., Henning, S. M., & Custer, L. J. (2005). Bioavailability andantioxidant effects of orange juice components in humans. Journal of agricultural and foodchemistry, 53(13), 5170-5178.

71. Franke, S. I. R., Prá, D., Giulian, R., Dias, J. F., Yoneama, M. L., Da Silva, J., … & Henriques,J. A. P. (2006). Influence of orange juice in the levels and in the genotoxicity of iron andcopper. Food and Chemical Toxicology, 44(3), 425-435.

72. Frerot, E., & Decorzant, E. (2004). Quantification of total furocoumarins in citrus oils byHPLC coupled with UV, fluorescence, and mass detection. Journal of agricultural and foodchemistry, 52(23), 6879-6886.

73. Fugh-Berman, A., & Myers, A. (2004). Citrus aurantium, an ingredient of dietary supplementsmarketed for weight loss: current status of clinical and basic research. Experimental biologyand medicine, 229(8), 698-704.

74. Galati, E. M., Monforte, M. T., Kirjavainen, S., Forestieri, A. M., Trovato, A., & Tripodo, M.M. (1994). Biological effects of hesperidin, a citrus flavonoid.(Note I): antiinflammatory andanalgesic activity. Farmaco (Societa chimica italiana: 1989),40(11), 709-712.

75. Garau, M. C., Simal, S., Rossello, C., & Femenia, A. (2007). Effect of air-drying temperatureon physico-chemical properties of dietary fibre and antioxidant capacity of orange (Citrusaurantium v. Canoneta) by-products. Food chemistry, 104(3), 1014-1024.

76. Garcia, A. C., Bonifácio, N. P., Vendramine, R. C., & Cesar, T. B. (2008). Influência doconsumo de suco de laranja nos lípides sangüíneos e na composição corporal de homensnormais e com dislipidemia. Nutrire, 33(2), 1-11.

77. Gardana, C., Guarnieri, S., Riso, P., Simonetti, P., & Porrini, M. (2007). Flavanone plasmapharmacokinetics from blood orange juice in human subjects. British journal ofnutrition, 98(01), 165-172.

78. Gattuso, G., Barreca, D., Gargiulli, C., Leuzzi, U., & Caristi, C. (2007). Flavonoid compositionof citrus juices. Molecules, 12(8), 1641-1673.

79. Gattuso, G., Caristi, C., Gargiulli, C., Bellocco, E., Toscano, G., & Leuzzi, U. (2006).Flavonoid glycosides in bergamot juice (Citrus bergamia Risso). Journal of agricultural andfood chemistry, 54(11), 3929-3935.

80. Ghanim, H., Mohanty, P., Pathak, R., Chaudhuri, A., Sia, C. L., & Dandona, P. (2007). Orangejuice or fructose intake does not induce oxidative and inflammatory response. Diabetes

care, 30(6), 1406-1411.

81. Ghanim, H., Sia, C. L., Upadhyay, M., Korzeniewski, K., Viswanathan, P., Abuaysheh, S., … &Dandona, P. (2010). Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. TheAmerican journal of clinical nutrition, 91(4), 940-949.

82. Ghasemi, K., Ghasemi, Y., & Ebrahimzadeh, M. A. (2009). Antioxidant activity, phenol andflavonoid contents of 13 citrus species peels and tissues. Pak J Pharm Sci, 22(3), 277-281.

83. Gil-Izquierdo, A., Gil, M. I., & Ferreres, F. (2002). Effect of processing techniques at industrialscale on orange juice antioxidant and beneficial health compounds. Journal of Agricultural andFood Chemistry, 50(18), 5107-5114.

84. Gil-Izquierdo, A., Gil, M. I., Ferreres, F., & Tomás-Barberán, F. A. (2001). In vitro availability

of flavonoids and other phenolics in orange juice. Journal of Agricultural and Food

Chemistry, 49(2), 1035-1041. solubility and transformation to chalconesunder gastrointestinal conditions. Journal of agricultural and food chemistry, 51(10), 3024-

3028.

86. Giménez-Bastida, J. A., González-Sarrías, A., Vallejo, F., Espín, J. C., & Tomás-Barberán, F. A.(2016). Hesperetin anits sulfate and glucuronide metabolites inhibit TNF- α induced humanaortic endothelial cell migration and decrease plasminogen activator inhibitor-1 (PAI-1)levels. Food & function.

87. Goes, T. C., Antunes, F. D., Alves, P. B., & Teixeira-Silva, F. (2012). Effect of sweet orangearoma on experimental anxiety in humans. The Journal of Alternative and ComplementaryMedicine, 18(8), 798-804.

88. González-Molina, E., Domínguez-Perles, R., Moreno, D. A., & García-Viguera, C. (2010).Natural bioactive compounds of Citrus limon for food and health. Journal of pharmaceuticaland biomedical analysis,51(2), 327-345.

89. Gray, S., & Woolf, A. D. (2005). Citrus aurantium used for weight loss by an adolescent withanorexia nervosa. Journal of adolescent health, 37(5), 414-415.

90. Green, C. O., Wheatley, A. O., Osagie, A. U., Morrison, E. Y. S. A., & Asemota, H. N. (2007).Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus(Citrus spp.) cultivars by high ‐performance liquid chromatography. Biomedical

chromatography, 21(1), 48-54.

91. Grosso, G., Galvano, F., Mistretta, A., Marventano, S., Nolfo, F., Calabrese, G., … & Scuderi,A. (2013). Red orange: experimental models and epidemiological evidence of its benefits onhuman health. Oxidative medicine and cellular longevity,2013.

92. Guadagni, D. G., Maier, V. P., & Turnbaugh, J. G. (1973). Effect of some citrus juiceconstituents on taste threshold for limonin and naringin bitterness. Journal of the Science ofFood and Agriculture,24(10), 1277-1288.

93. Guarnieri, S., Riso, P., & Porrini, M. (2007). Orange juice vs vitamin C: effect on hydrogenperoxide-induced DNA damage in mononuclear blood cells. British journal of nutrition,97(04), 639-643.

94. Guthrie, N., & Carroll, K. K. (1998). Inhibition of mammary cancer by citrus flavonoids.In Flavonoids in the Living System (pp. 227-236). Springer US.

95. Haaz, S., Fontaine, K. R., Cutter, G., Limdi, N., Perumean‐Chaney, S., & Allison, D. B. (2006).Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: anupdate. Obesity reviews, 7(1), 79-88.

96. Hansen, D. K., George, N. I., White, G. E., Pellicore, L. S., Abdel-Rahman, A., Fabricant, D.,& Food and Drug Administration. (2012). Physiological effects following administration ofCitrus aurantium for 28days in rats. Toxicology and applied pharmacology,261(3), 236-247.

97. Harats, D., Chevion, S., Nahir, M., Norman, Y., Sagee, O., & Berry, E. M. (1998). Citrus fruitsupplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturatedfat: presumptive evidence for an interaction between vitamins C and E in vivo. The American

journal of clinical nutrition, 67(2), 240-245.

98. Hashemi, M., Khosravi, E., Ghannadi, A., Hashemipour, M., & Kelishadi, R. (2015). Effect ofthe peels of two Citrus fruits on endothelium function in adolescents with excess weight: Atriple-masked randomized trial. Journal of Research in Medical Sciences: The Official Journalof Isfahan University of Medical Sciences, 20(8), 721.

99. Honda, Y., Ushigome, F., Koyabu, N., Morimoto, S., Shoyama, Y., Uchiumi, T., … & Sawada,Y. (2004). Effects of grapefruit juice and orange juice components on P ‐ glycoprotein ‐andMRP2 ‐mediated drug efflux. British journal of pharmacology, 143(7), 856-864.

100. Huang, Y. T., Wang, G. F., Chen, C. F., Chen, C. C., Hong, C. Y., & Yang, M. C. (1995).Fructus aurantii reduced portal pressure in portal hypertensive rats. Life sciences, 57(22), 2011-2020.

101. Ikegawa, T., Ushigome, F., Koyabu, N., Morimoto, S., Shoyama, Y., Naito, M., … & Sawada, Y.(2000). Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones inadriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer letters, 160(1),21-28.

102. Jafarzadeh, M., Arman, S., & Pour, F. F. (2013). Effect of aromatherapy with orange essentialoil on salivary cortisol and pulse rate in children during dental treatment: a randomizedcontrolled clinical trial. Advanced biomedical research, 2.

103. Jayaprakasha, G. K., & Patil, B. S. (2007). In vitro evaluation of the antioxidant activities infruit extracts from citron and blood orange. Food Chemistry, 101(1), 410-418.

104. Jayaprakasha, G. K., Mandadi, K. K., Poulose, S. M., Jadegoud, Y., Gowda, G. N., & Patil, B.S. (2008). Nove triterpenoid from Citrus aurantium L. possesses chemopreventive propertiesagainst human colon cancer cells. Bioorganic & medicinal chemistry, 16(11), 5939-5951.

105. Johnston, C. S., Dancho, C. L., & Strong, G. M. (2003). Orange juice ingestion andsupplemental vitamin C are equally effective at reducing plasma lipid peroxidation in healthyadult women. Journal of the American College o Nutrition, 22(6), 519-523.

106. Jordan, S., Murty, M., & Pilon, K. (2004). Products containing bitter orange or synephrine:suspected cardiovascular adverse reactions. Canadian Medical Association. Journal, 171(8),993.

107. Kaats, G. R., Miller, H., Preuss, H. G., & Stohs, S. J. (2013). A 60 day double-blind, placebo-controlled safety studyinvolving Citrus aurantium (bitter orange) extract. Food and ChemicalToxicology, 55, 358-362.

108. Kamaraj, S., Ramakrishnan, G., Anandakumar, P., Jagan, S., & Devaki, T. (2009). Antioxidantand anticancer efficacy of hesperidin in benzo (a) pyrene induced lung carcinogenesis inmice. Investigational new drugs, 27(3), 214-222.

109. Kanaze, F. I., Gabrieli, C., Kokkalou, E., Georgarakis, M., & Niopas, I. (2003). Simultaneousreversed-phase high-performance liquid chromatographic method for the determination ofdiosmin, hesperidin and naringin in different citrus fruit juices and pharmaceuticalformulations. Journal of Pharmaceutical and Biomedical Analysis, 33(2), 243-249.

110. Kang, M., Kim, J. H., Cho, C., Chung, H. S., Kang, C. W., Kim, Y., … & Bae, H. (2007). Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart. Journal of ethnopharmacology, 111(3), 584-591.

111. Kawaii, S., Tomono, Y., Katase, E., Ogawa, K., Nonomura-Nakano, M., Nesumi, H., … &Yano, M. (2001). Quantitative study of fruit flavonoids in Citrus hybrids of King (C. nobilis)and Mukaku Kishu (C. kinokuni). Journal of agricultural and food chemistry,49(8), 3982-3986.

112. Ke, J. Y., Cole, R. M., Hamad, E. M., Hsiao, Y. H., Cotten, B. M., Powell, K. A., & Belury, M.A. (2015). Citrus flavonoid, naringenin, increases locomotor activity and reducesdiacylglycerol accumulation in skeletal muscle of obese ovariectomized mice. Molecular  nutrition & food research.

113. Keevil, J. G., Osman, H. E., Reed, J. D., & Folts, J. D. (2000). Grape juice, but not orange juiceor grapefruit juice, inhibits human platelet aggregation. The Journal of nutrition, 130(1), 53-56.

114. Kelebek, H., Selli, S., Canbas, A., & Cabaroglu, T. (2009). HPLC determination of organic acids, sugars, phenolic compositions and antioxidant capacity of orange juice and orange wine made from a Turkish cv. Kozan. Microchemical Journal, 91(2), 187-192.

115. Kim, D. B., Shin, G. H., Kim, J. M., Kim, Y. H., Lee, J. H., Lee, J. S., … & Lee, O. H. (2016).Antioxidant and anti-ageing activities of citrus-based juice mixture. Food chemistry, 194, 920-927.

116. Kimira, Y., Taniuchi, Y., Nakatani, S., Sekiguchi, Y., Kim, H. J., Shimizu, J., … & Mano, H.(2015). Citrus limonoid nomilin inhibits osteoclastogenesis in vitro by suppression of NFATc1

and MAPK signaling pathways. Phytomedicine, 22(12), 1120-1124.

117. Klimczak, I., Małecka, M., Szlachta, M., & Gliszczyńska-Świgło, A. (2007). Effect of storageon the content of polyphenols, vitamin C and the antioxidant activity of orange juices. Journalof Food Composition and Analysis, 20(3), 313-322.

118. Knekt, P., Järvinen, R., Seppänen, R., Heliövaara, M., Teppo, L., Pukkala, E., & Aromaa, A.(1997). Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.American Journal of Epidemiology, 146(3), 223-230.

119. Kohno, H., Taima, M., Sumida, T., Azuma, Y., Ogawa, H., & Tanaka, T. (2001). Inhibitoryeffect of mandarin juice rich in β-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice. Cancer letters, 174(2), 141-150.120. Koitabashi, Y. U., Kumai, T., Matsumoto, N., Watanabe, M., Sekine, S., Yanagida, Y., &

Kobayashi, S. (2006). Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-

methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life sciences,

78(24), 2852-2859.

121. Kurowska, E. M., & Manthey, J. A. (2004). Hypolipidemic effects and absorption of citrus

polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. Journal of

Agricultural and Food Chemistry, 52(10), 2879-2886.

122. Kurowska, E. M., Borradaile, N. M., Spence, J. D., & Carroll, K. K. (2000).

Hypocholesterolemic effects of dietary citrus juices in rabbits. Nutrition Research, 20(1), 121-

129.

123. Kurowska, E. M., Spence, J. D., Jordan, J., Wetmore, S., Freeman, D. J., Piché, L. A., &

Serratore, P. (2000). HDL-cholesterol-raising effect of orange juice in subjects with

hypercholesterolemia. The American journal of clinical nutrition, 72(5), 1095-1100.

124. Lee, C. J., Wilson, L., Jordan, M. A., Nguyen, V., Tang, J., & Smiyun, G. (2010). Hesperidin

suppressed proliferations of both Human breast cancer and androgen ‐dependent prostate cancer

cells. Phytotherapy Research, 24(S1), S15-S19.

125. Lee, D. H., Park, K. I., Park, H. S., Kang, S. R., Nagappan, A., Kim, J. A., … & An, S. J.

(2011). Flavonoids isolated from Korea Citrus aurantium L. induce G2/M phase arrest and

apoptosis in human gastric cancer AGS cells. Evidence-Based Complementary and Alternative

Medicine, 2012.

126. Lee, H. S., & Chen, C. S. (1998). Rates of vitamin C loss and discoloration in clear orange

juice concentrate during storage at temperatures of 4-24 C. Journal of Agricultural and Food

Chemistry, 46(11), 4723-4727.

127. Lee, S. H., Yumnam, S., Hong, G. E., Raha, S., Venkatarame Gowda Saralamma, V., Lee, H. J.,

… & Park, H. S. (2015). Flavonoids of Korean Citrus aurantium L. Induce Apoptosis via

Intrinsic Pathway in Human Hepatoblastoma HepG2 Cells. Phytotherapy Research, 29(12),

1940-1949.

128. Lehrer, S., Green, S., & Rosenzweig, K. E. (2016). Melanoma risk and citrus

consumption. Journal of Clinical Oncology, JCO638254.

129. Lehrner, J., Marwinski, G., Lehr, S., Johren, P., & Deecke, L. (2005). Ambient odors of orange

and lavender reduce anxiety and improve mood in a dental office. Physiology &

Behavior, 86(1), 92-95.

130. Leite, M. P., Fassin Jr, J., Baziloni, E. M., Almeida, R. N., Mattei, R., & Leite, J. R. (2008).

Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats. Revista Brasileira

de Farmacognosia, 18, 661-666.

131. Leopoldini, M., Malaj, N., Toscano, M., Sindona, G., & Russo, N. (2010). On the inhibitor

effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase

(HMGR) enzyme. Journal of agricultural and food chemistry, 58(19), 10768-10773.

132. Leuzzi, U., Caristi, C., Panzera, V., & Licandro, G. (2000). Flavonoids in pigmented orange

juice and second-pressure extracts. Journal of agricultural and food chemistry, 48(11), 5501-

5506.

133. Li, H., Yang, B., Huang, J., Xiang, T., Yin, X., Wan, J., … & Ren, G. (2013). Naringin inhibits

growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling

pathway. Toxicology letters, 220(3), 219-228.

134. Lilja, J. J., Juntti‐Patinen, L., & Neuvonen, P. J. (2004). Orange juice substantially reduces the

bioavailability of the β ‐adrenergic–blocking agent celiprolol. Clinical Pharmacology &

Therapeutics, 75(3), 184-190.

135. Lim, H., Yeo, E., Song, E., Chang, Y. H., Han, B. K., Choi, H. J., & Hwang, J. (2015).

Bioconversion of Citrus unshiu peel extracts with cytolase suppresses adipogenic activity in

3T3-L1 cells. Nutrition research and practice, 9(6), 599-605.

136. Lima CG, Basile LG, Silveira JQ, Cesar TB. 2012. Regular intake of red orange juice reduces

blood pressure in adults. J Health Sci Inst 30: 59–63.

137. Luckow, T., & Delahunty, C. (2004). Consumer acceptance of orange juice containing

functional ingredients. Food Research International, 37(8), 805-814.

138. Luo, G., Guan, X., & Zhou, L. (2008). Apoptotic effect of citrus fruit extract nobiletin on lung

cancer cell line A549 in vitro and in vivo. Cancer biology & therapy,7(6), 966-973.

139. Manach, C. 1., Morand, C., Gil-Izquierdo, A., Bouteloup-Demange, C., & Remesy, C. (2003).

Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two

doses of orange juice. European Journal of Clinical Nutrition,57(2), 235-242.

140. Mandalari, G., Bennett, R. N., Bisignano, G., Saija, A., Dugo, G., Lo Curto, R. B., … &

Waldron, K. W. (2006). Characterization of flavonoids and pectins from bergamot (Citrus

bergamia Risso) peel, a major byproduct of essential oil extraction. Journal of agricultural and

food chemistry, 54(1), 197-203.

141. Manthey, J. A., & Grohmann, K. (1996). Concentrations of hesperidin and other orange peel

flavonoids in citrus processing byproducts. Journal of Agricultural and Food Chemistry, 44(3),

811-814.

142. Manthey, J. A., & Guthrie, N. (2002). Antiproliferative activities of citrus flavonoids against

six human cancer cell lines. Journal of Agricultural and Food Chemistry, 50(21), 5837-5843.

143. Manthey, J. A., Guthrie, N., & Grohmann, K. (2001). Biological properties of citrus flavonoids

pertaining to cancer and inflammation. Current medicinal chemistry, 8(2), 135-153.

144. Martin BR, McCabe GP, McCabe L, Jackson GS, Horcajada MN, Offord-Cavin E, Peacock

M, Weaver CM. Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement on

Bone Health in Postmenopausal Women. J Clin Endocrinol Metab. 2016

145. Mattoli, L., Cangi, F., Maidecchi, A., Ghiara, C., Tubaro, M., & Traldi, P. (2005). A rapid liquid

chromatography electrospray ionization mass spectrometry n method for evaluation of

synephrine in Citrus aurantium L. samples. Journal of agricultural and food chemistry, 53(26),

9860-9866.

146. Meléndez-Martínez, A. J., Vicario, I. M., & Heredia, F. J. (2007). Carotenoids, color, and

ascorbic acid content of a novel frozen-marketed orange juice. Journal of agricultural and food

chemistry, 55(4), 1347-1355.

147. Meng, X. M., Zhang, Y., Huang, X. R., Ren, G. L., Li, J., & Lan, H. Y. (2015). Treatment of

renal fibrosis by rebalancing TGF- β/Smad signaling with the combination of asiatic acid and

naringenin. Oncotarget, 6(35), 36984-36997.

148. Middleton Jr, E., & Kandaswami, C. (1994). Potential health-promoting properties of citrus

flavonoids. Food technology (USA).

149. Milenkovic, D., Deval, C., Dubray, C., Mazur, A., & Morand, C. (2011). Hesperidin displays

relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human

volunteers: a randomized controlled cross-over study. PLoS One, 6(11), e26669.

150. Miller, E. G., Gonzales-Sanders, A. P., Couvillon, A. M., Binnie, W. H., Hasegawa, S., & Lam,

L. K. (1994). Citrus limonoids as inhibitors of oral carcinogenesis. Food technology, 48(11),

110-114.

151. Miyagi, Y., Om, A. S., Chee, K. M., & Bennink, M. R. (2000). Inhibition of azoxymethane-
induced colon cancer by orange juice. Nutrition and cancer,36(2), 224-229.

152. Mizrahi, S., & Berk, Z. (1970). Physico ‐chemical characteristics of orange juice cloud. Journal

of the Science of Food and Agriculture, 21(5), 250-253.

153. Moraes, T. M., Kushima, H., Moleiro, F. C., Santos, R. C., Rocha, L. R. M., Marques, M. O., …

& Hiruma-Lima, C. A. (2009). Effects of limonene and essential oil from Citrus aurantium on

gastric mucosa: role of prostaglandins and gastric mucus secretion. Chemico-Biological

Interactions, 180(3), 499-505.

154. Morand, C., Dubray, C., Milenkovic, D., Lioger, D., Martin, J. F., Scalbert, A., & Mazur, A.

(2011). Hesperidin contributes to the vascular protective effects of orange juice: a randomized

crossover study in healthy volunteers. The American journal of clinical nutrition, 93(1), 73-80.

155. Morin, B., Nichols, L. A., Zalasky, K. M., Davis, J. W., Manthey, J. A., & Holland, L. J. (2008).

The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein

receptor gene transcription in HepG2 liver cells. The Journal of nutrition, 138(7), 1274-1281.

156. Moufida, S., & Marzouk, B. (2003). Biochemical characterization of blood orange, sweet

orange, lemon, bergamot and bitter orange. Phytochemistry,62(8), 1283-1289.

157. Mouly, P. P., Gaydou, E. M., Arzouyan, C. R., & Estienne, J. M. (1996). Différenciation des jus

de Citrus par analyses statistiques multivariées. Partie II. Cas des oranges et des

mandarines. Analusis,24(6), 230-239.

158. Mullen, W., Archeveque, M. A., Edwards, C. A., Matsumoto, H., & Crozier, A. (2008).

Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat

yogurt. Journal of agricultural and food chemistry, 56(23), 11157-11164.

159. Nakajima, V. M., Madeira, J. V., Macedo, G. A., & Macedo, J. A. (2016). Biotransformation

effects on anti lipogenic activity of citrus extracts. Food chemistry, 197, 1046-1053.

160. Napoleone, E., Cutrone, A., Zurlo, F., Di Castelnuovo, A., D’Imperio, M., Giordano, L., … &

de Gaetano, G. (2013). Both red and blond orange juice intake decreases the procoagulant

activity of whole blood in healthy volunteers. Thrombosis research,132(2), 288-292.

161. Nielsen, I. L. F., Chee, W. S., Poulsen, L., Offord-Cavin, E., Rasmussen, S. E., Frederiksen, H.,

… & Williamson, G. (2006). Bioavailability is improved by enzymatic modification of the

citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial. The Journal

of nutrition, 136(2), 404-408.

162. Nogata, Y., Sakamoto, K., Shiratsuchi, H., Ishii, T., Yano, M., & Ohta, H. (2006). Flavonoid

composition of fruit tissues of citrus species. Bioscience, biotechnology, and

biochemistry, 70(1), 178-192.

163. Nouri, A., & Shafaghatlonbar, A. (2015). Chemical constituents and antioxidant activity of

essential oil and organic extract from the peel and kernel parts of Citrus japonica Thunb.

(kumquat) from Iran. Natural product research, 1-5.

164. O’Bryan, C. A., Crandall, P. G., Chalova, V. I., & Ricke, S. C. (2008). Orange essential oils

antimicrobial activities against Salmonella spp. Journal of food science, 73(6), M264-M267.

165. Odvina, C. V. (2006). Comparative value of orange juice versus lemonade in reducing stone-
forming risk .Clinical Journal of the American Society of Nephrology, 1(6), 1269-1274.

166. Ooghe, W. C., & Detavernier, C. L. M. (1997). Detection of the addition of Citrus reticulata

and hybrids to Citrus sinensis by flavonoids. Journal of Agricultural and Food

Chemistry, 45(5), 1633-1637.

167. Ooghe, W. C., Ooghe, S. J., Detavernier, C. L. M., & Huyghebaert, A. (1994). Characterization

of orange juice (Citrus sinensis) by flavanone glycosides. Journal of Agricultural and Food

Chemistry, 42(10), 2183-2190.

168. Ooghe, W. C., Ooghe, S. J., Detavernier, C. L. M., & Huyghebaert, A. (1994). Characterization

of orange juice (Citrus sinensis) by polymethoxylated flavones.Journal of Agricultural and

Food Chemistry, 42(10), 2191-2195.

169. Ortuno, A., Benavente-Garcia, O., Castillo, J., Alcaraz, M., Vicente, V., & Del Rio, J. A.

(2007). Beneficial action of Citrus flavonoids on multiple cancer-related biological pathways.

Current cancer drug targets, 7(8), 795-809.

170. Ou, M. C., Liu, Y. H., Sun, Y. W., & Chan, C. F. (2015). The Composition, Antioxidant and

Antibacterial Activities of Cold-Pressed and Distilled Essential Oils of Citrus paradisi and

Citrus grandis (L.) Osbeck. Evidence-Based Complementary and Alternative Medicine, 2015.

171. Patil, J. R., Jayaprakasha, G. K., Murthy, K. C., Chetti, M. B., & Patil, B. S. (2010).

Characterization of Citrus aurantifolia bioactive compounds and their inhibition of human

pancreatic cancer cells through apoptosis. Microchemical Journal, 94(2), 108-117.

172. Pellati, F., & Benvenuti, S. (2007). Chromatographic and electrophoretic methods for the

analysis of phenetylamine alkaloids in Citrus aurantium. Journal of Chromatography

A, 1161(1), 71-88.

173. Pellati, F., Benvenuti, S., Melegari, M., & Firenzuoli, F. (2002). Determination of adrenergic

agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC. Journal of

pharmaceutical and biomedical analysis, 29(6), 1113-1119.

174. Penzak, S. R., Jann, M. W., Cold, J. A., Hon, Y. Y., Desai, H. D., & Gurley, B. J. (2001). Seville

(sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. The

Journal of Clinical Pharmacology, 41(10), 1059-1063.

175. Peterson, J. J., Dwyer, J. T., Beecher, G. R., Bhagwat, S. A., Gebhardt, S. E., Haytowitz, D. B.,

& Holden, J. M. (2006). Flavanones in oranges, tangerines (mandarins), tangors, and tangelos:

a compilation and review of the data from the analytical literature. Journal of Food

Composition and Analysis,19, S66-S73.

176. Polydera, A. C., Stoforos, N. G., & Taoukis, P. S. (2004). The effect of storage on the

antioxidant activity of reconstituted orange juice which had been pasteurized by high pressure

or heat. International journal of food science & technology, 39(7), 783-791.

177. Polydera, A. C., Stoforos, N. G., & Taoukis, P. S. (2005). Effect of high hydrostatic pressure

treatment on post processing antioxidant activity of fresh Navel orange juice. Food

Chemistry, 91(3), 495-503.

178. Proteggente, A. R., Saija, A., De Pasquale, A., & Rice-Evans, C. A. (2003). The compositional

characterisation and antioxidant activity of fresh juices from sicilian sweet orange (Citrus

sinensis L. Osbeck) varieties. Free radical research, 37(6), 681-687.

179. Pupin, A. M., Dennis, M. J., & Toledo, M. C. F. (1998). Polymethoxylated flavones in Brazilian

orange juice. Food chemistry, 63(4), 513-518.

180. Rangel-Huerta, O. D., Aguilera, C. M., Martin, M. V., Soto, M. J., Rico, M. C., Vallejo, F., … &

Mesa, M. D. (2015). Normal or High Polyphenol Concentration in Orange Juice Affects

Antioxidant Activity, Blood Pressure, and Body Weight in Obese or Overweight Adults. The

Journal of nutrition, 145(8), 1808-1816.

181. Rapisarda, P., Carollo, G., Fallico, B., Tomaselli, F., & Maccarone, E. (1998).

Hydroxycinnamic acids as markers of Italian blood orange juices. Journal of Agricultural and

Food Chemistry, 46(2), 464-470.

182. Rapisarda, P., Tomaino, A., Lo Cascio, R., Bonina, F., De Pasquale, A., & Saija, A. (1999).

Antioxidant effectiveness as influenced by phenolic content of fresh orange juices. Journal of

Agricultural and Food Chemistry, 47(11), 4718-4723.

183. Riso, P., Visioli, F., Gardana, C., Grande, S., Brusamolino, A., Galvano, F., … & Porrini, M.

(2005). Effects of blood orange juice intake on antioxidant bioavailability and on different

markers related to oxidative stress. Journal of agricultural and food chemistry, 53(4), 941-947.

184. Robards, K., & Antolovich, M. (1995). Methods for assessing the authenticity of orange juice.

A review. Analyst, 120(1), 1-28.

185. Rodrigues, M., Alves, G., & Falcão, A. (2013). Investigating herb–drug interactions: the effect

of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats. Food and

Chemical Toxicology, 60, 153-159.

186. Rossato, L. G., Costa, V. M., Limberger, R. P., de Lourdes Bastos, M., & Remião, F. (2011).

Synephrine: from trace concentrations to massive consumption in weight-loss. Food and

chemical toxicology, 49(1), 8-16.

187. Rouseff, R. L., Martin, S. F., & Youtsey, C. O. (1987). Quantitative survey of narirutin,

naringin, hesperidin, and neohesperidin in citrus. Journal of Agricultural and Food

Chemistry, 35(6), 1027-1030.

188. Roza, J. M., Xian-Liu, Z., & Guthrie, N. (2007). Effect of citrus flavonoids and tocotrienols on

serum cholesterol levels in hypercholesterolemic subjects. Alternative therapies in health and

medicine, 13(6), 44.

189. Sánchez-Moreno, C., Cano, M. P., de Ancos, B., Plaza, L., Olmedilla, B., Granado, F., &

Martín, A. (2003). Effect of orange juice intake on vitamin C concentrations and biomarkers of

antioxidant status in humans. The American journal of clinical nutrition,78(3), 454-460.

190. Sánchez-Moreno, C., Plaza, L., de Ancos, B., & Cano, M. P. (2003). Vitamin C, provitamin A

carotenoids, and other carotenoids in high-pressurized orange juice during refrigerated storage.

Journal of agricultural and food chemistry,51(3), 647-653.

191. Sánchez-Moreno, C., Plaza, L., de Ancos, B., & Cano, P. M. (2003). Effect of high-pressure

processing on health-promoting attributes of freshly squeezed orange juice (Citrus sinensis L.)

during chilled storage. European Food Research and Technology, 216(1), 18-22.

192. Sánchez-Moreno, C., Plaza, L., Elez-Martínez, P., De Ancos, B., Martín-Belloso, O., & Cano,

M. P. (2005). Impact of high pressure and pulsed electric fields on bioactive compounds and

antioxidant activity of orange juice in comparison with traditional thermal processing. Journal

of Agricultural and Food Chemistry, 53(11), 4403-4409.

193. Santana, J., Sharpless, K. E., & Nelson, B. C. (2008). Determination of para-synephrine and

meta-synephrine positional isomers in bitter orange-containing dietary supplements by LC/UV

and LC/MS/MS. Food chemistry, 109(3), 675-682.

194. Scalzo, R. L., Iannoccari, T., Summa, C., Morelli, R., & Rapisarda, P. (2004). Effect of thermal

treatments on antioxidant and antiradical activity of blood orange juice. Food chemistry, 85(1),

41-47.

195. Seifert JG, Burke ER, Devonish R, Nelson A, Bacharach DW. The effects of acute citrus

aurantium ingestion on energy expenditure in mildly obese subjects(abstr). Med Sci Sports

Exerc 2003;35:S248.

196. Si-Ahmed, K., Tazerouti, F., Badjah-Hadj-Ahmed, A. Y., Aturki, Z., D’Orazio, G., Rocco, A., &

Fanali, S. (2010). Analysis of hesperetin enantiomers in human urine after ingestion of blood

orange juice by using nano-liquid chromatography. Journal of pharmaceutical and biomedical

analysis, 51(1), 225-229.

197. Silalahi, J. (2002). Anticancer and health protective properties of citrus fruit components. Asia

Pacific journal of clinical nutrition, 11(1), 79-84.

198. Silveira, J. Q., Dourado, G. K., & Cesar, T. B. (2015). Red-fleshed sweet orange juice improves

the risk factors for metabolic syndrome. International journal of food sciences and

nutrition, 66(7), 830-836.

199. Singh, D., Chander, V., & Chopra, K. (2004). Protective effect of naringin, a bioflavonoid on

glycerol-induced acute renal failure in rat kidney.Toxicology, 201(1), 143-151.

200. So, F. V., Guthrie, N., Chambers, A. F., Moussa, M., & Carroll, K. K. (1996). Inhibition of

human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and

citrus juices. Nutrition and Cancer. Volume 26, Issue 2, 1996

201. Sousa, W. R., da Rocha, C., Cardoso, C. L., Silva, D. H. S., & Zanoni, M. V. B. (2004).

Determination of the relative contribution of phenolic antioxidants in orange juice by

voltammetric methods. Journal of Food Composition and Analysis, 17(5), 619-633.

202. Sridharan, B., Micheal, S. T., Ramachandran, A., Ganesh, R. N., & Viswanathan, P. Citrus

bioflavonoids ameliorate hyperoxaluria induced renal injury and calcium oxalate crystal

deposition in Wistar rats. Adv Pharm Bull. 2015 Sep;5(3):419-27

203. Stohs, S. J. (2010). Assessment of the adverse event reports associated with Citrus aurantium

(Bitter orange) from April 2004 to October 2009. Journal of Functional Foods, 2(4), 235-238.

204. Sun, Y., Zhang, H., Sun, Y., Zhang, Y., Liu, H., Cheng, J., … & Zhang, H. (2010). Study of

interaction between protein and main active components in Citrus aurantium L. by optical

spectroscopy. Journal of Luminescence, 130(2), 270-279.

205. Takanaga, H., Ohnishi, A., Yamada, S., Matsuo, H., Morimoto, S., Shoyama, Y., … & Sawada,

Y. (2000). Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not

cytochrome P450 3A4. Journal of Pharmacology and Experimental Therapeutics, 293(1), 230-

236.

206. Takei, H., Hirabuki, M., & Yoshizaki, F. (1999). Analysis of Synephrine in the Peel of Citrus

Fruit, Immature Citrus Fruit and Decoctions of Chinese Medicinal Prescriptions Containing

These Crude Drugs by Capillary Electrophoresis. Analytical sciences, 15(10), 1017-1020.

207. Tanaka, T., Kohno, H., Murakami, M., Shimada, R., Kagami, S., Sumida, T., … & Ogawa, H.

(2000). Suppression of azoxymethane ‐induced colon carcinogenesis in male F344 rats by

mandarin juices rich in β ‐cryptoxanthin and hesperidin. International Journal of Cancer, 88(1),

146-150.

208. Tao, N. G., Liu, Y. J., & Zhang, M. L. (2009). Chemical composition and antimicrobial

activities of essential oil from the peel of bingtang sweet orange (Citrus sinensis Osbeck).

International journal of food science & technology,44(7), 1281-1285.

209. Titta, L., Trinei, M., Stendardo, M., Berniakovich, I., Petroni, K., Tonelli, C., … & Rapisarda, P.

(2010). Blood orange juice inhibits fat accumulation in mice. International Journal of

Obesity, 34(3), 578-588.

210. Tripoli, E., La Guardia, M., Giammanco, S., Di Majo, D., & Giammanco, M. (2007). Citrus

flavonoids: Molecular structure, biological activity and nutritional properties: A review. Food

chemistry, 104(2), 466-479.

211. Tsiraki, M. I., & Savvaidis, I. N. (2016). The effects of citrus extract (Citrox©) on the naturally

occurring microflora and inoculated pathogens, Bacillus cereus and Salmonella enterica, in a

model food system and the traditional Greek yogurt-based salad Tzatziki. Food

microbiology, 53, 150-155.

212. Tuyns, A. J. (1983). Protective effect of citrus fruit on esophageal cancer. Nutr Cancer

1983; 5:195–200

213. Vanamala, J., Reddivari, L., Yoo, K. S., Pike, L. M., & Patil, B. S. (2006). Variation in the

content of bioactive flavonoids in different brands of orange and grapefruit juices. Journal of

Food Composition and Analysis, 19(2), 157-166.

214. Verzera, A., Trozzi, A., Dugo, G., Di Bella, G., & Cotroneo, A. (2004). Biological lemon and

sweet orange essential oil composition. Flavour and fragrance journal, 19(6), 544-548.

215. Verzera, A., Trozzi, A., Gazea, F., Cicciarello, G., & Cotroneo, A. (2003). Effects of rootstock

on the composition of bergamot (Citrus bergamia Risso et Poiteau) essential oil. Journal of

agricultural and food chemistry, 51(1), 206-210.

216. Vinson, J. A., & Bose, P. (1988). Comparative bioavailability to humans of ascorbic acid alone

or in a citrus extract. The American journal of clinical nutrition, 48(3), 601-604.

217. Vinson, J. A., Liang, X., Proch, J., Hontz, B. A., Dancel, J., & Sandone, N. (2002). Polyphenol

antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease. In Flavonoids

in Cell Function (pp. 113-122). Springer US.

218. Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., & Pérez-Álvarez, J. (2008).

Antifungal activity of lemon (Citrus lemon L.), mandarin (Citrus reticulata L.), grapefruit

(Citrus paradisi L.) and orange (Citrus sinensis L.) essential oils. Food control, 19(12), 1130-

1138.

219. Wabner, C. L., & Pak, C. Y. (1993). Effect of orange juice consumption on urinary stone risk

factors. The Journal of urology, 149(6), 1405-1408.

220. Wang, A., Zhu, C., Fu, L., Wan, X., Yang, X., Zhang, H., … & Zhao, H. (2015). Citrus Fruit

Intake Substantially Reduces the Risk of Esophageal Cancer: A Meta-Analysis of

Epidemiologic Studies. Medicine, 94(39).

221. Whitman, S. C., Kurowska, E. M., Manthey, J. A., & Daugherty, A. (2005). Nobiletin, a citrus

flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated

metabolism of acetylated LDL by mouse macrophages. Atherosclerosis, 178(1), 25-32.

222. Wilmsen, P. K., Spada, D. S., & Salvador, M. (2005). Antioxidant activity of the flavonoid

hesperidin in chemical and biological systems. Journal of agricultural and food

chemistry, 53(12), 4757-4761.

223. Wu, S., Han, J., Feskanich, D., Cho, E., Stampfer, M. J., Willett, W. C., & Qureshi, A. A.

(2015). Citrus consumption and risk of cutaneous malignant melanoma. Journal of Clinical

Oncology, JCO-2014.

224. Xing, H., Zhang, K., Zhang, R., Shi, H., Bi, K., & Chen, X. (2015). Antidepressant-like effect

of the water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and

Magnolia officinalis in a rat model of chronic unpredictable mild stress. Phytomedicine, 22(13),

1178-1185.

225. Xiong, Y., Chang, M., Deng, K., & Luo, Y. (2016). A new phenolic glycoside and two new

monoterpenoid furocoumarins from Aurantii Fructus Immaturus. Natural product research, 1-

6.

226. Xu, J. J., Liu, Z., Tang, W., Wang, G. C., Chung, H. Y., Liu, Q. Y., … & Li, Y. L. (2015).

Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and

Associated Inflammation in Vivo. Journal of agricultural and food chemistry, 63(43), 9520-

9527.

227. Yamamoto, M., Suzuki, A., & Hase, T. (2008). Short-term effects of glucosyl hesperidin and

hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive

rats. Journal of nutritional science and vitaminology, 54(1), 95-98.

228. Yip, Y. B., & Tam, A. C. Y. (2008). An experimental study on the effectiveness of massage with

aromatic ginger and orange essential oil for moderate-to-severe knee pain among the elderly in

Hong Kong. Complementary therapies in medicine, 16(3), 131-138.

229. Zhou, X. M., Cao, Z. D., Xiao, N., Shen, Q., & Li, J. X. (2016). Inhibitory effects of amines

from Citrus reticulata on bleomycin-induced pulmonary fibrosis in rats. International journal

of molecular medicine,37(2), 339-346.

230. Zou, Z., Xi, W., Hu, Y., Nie, C., & Zhou, Z. (2016). Antioxidant activity of Citrus fruits. Food

chemistry,196, 885-896.

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